Fri Oct 03 2025

97 articles - From Friday Sep 26 2025 to Friday Oct 03 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

J Neurogastroenterol Motil
2025 Focused Update of the Seoul Consensus on Gastroesophageal Reflux Disease: Evidence-based Recommendations on Acid Suppressive Therapy.

Six key statements are presented: updated definition and classification of GERD (Statement 1); initial and long-term treatment strategies tailored to GERD phenotypes, such as non-erosive reflux disease, mild erosive esophagitis, and severe erosive esophagitis (Statements 2-5); and dose optimization strategies for long-term safety (Statement 6). These guidelines aim to support gastroenterologists and general healthcare providers in making individualized evidence-based decisions for GERD management.

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Meta-analysis

meta-analyses and systematic reviews

Gastrointest Endosc
Transoral Outlet Reduction for the Treatment of Dumping Syndrome After Roux-En-Y Gastric Bypass: A Systematic Review and Meta-Analysis.

Our study concludes that TORe is an effective and safe procedure for treating DS among RYGB patients.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression.

Our study reveals that gut microbiota dysbiosis is implicated in CPH progression, potentially providing new avenues for microbiome-based treatment for CPH.

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Am J Gastroenterol
Correlation and Assessment of Small Bowel Lesions Using Cross-Sectional Imaging Techniques Compared With Small Intestinal Contrast Ultrasonography in Known Crohn's Disease (the CACTUS-CD Study): A Paired, Prospective, Confirmatory Study.

IUS is a highly accurate, noninvasive tool for monitoring SB CD, with SICUS enhancing stricture detection. Although CTE/MRE remains essential for evaluating proximal and mid-SB disease and surgical planning, the limited overall incremental impact support a scalable, ultrasound-first approach (ClinicalTrials.gov NCT06125678).

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Elevation of tTG-IgA Antibodies in a Prospective Cohort of Children at Risk of Celiac Disease: Insights From the CDGEMM Cohort.

We found that al subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.

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Global prevalence, characterization and impact of Functional Bowel Disorders.

FBD are common globally with minor differences across regions and countries and with prominent effects on health and daily life. Relatively minor diagnostic criteria changes can affect IBS prevalence rates substantially, but the negative health impact remains.

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Gut microbiota are more strongly associated with impairments in health-related quality of life than disease activity in inflammatory bowel disease.

Alterations in gut microbiota are associated with HRQoL outcomes in patients with IBD and healthy controls.

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Impact of Prior Upper Endoscopy on Gastric Cancer Stage and Survival in Older Adults.

Prior EGD is associated with earlier stage and improved survival in older adults. This study supports further research into endoscopic screening in the U.S. across younger age groups and diverse populations and healthcare settings.

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Incomplete Polyp Resection Rate of Colorectal Polyps in the Chinese Population: A Cross-Sectional Study.

The IRR of polyps varies greatly in clinical practice, even among experienced endoscopists. SSA/Ps and polyps located in the proximal colon tend to be incompletely resected, and a high level of NBI experience might help reduce the IRR.

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Increasing Goals of Care Discussions Among Veterans with Cirrhosis: A Veterans Health Administration Quality Improvement Initiative.

GCD documentation increased over time in the context of targeted QI initiatives. Future interventions should be conducted earlier and address illness understanding.

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Pregnancy Outcomes After Maternal or Paternal Exposure to Tofacitinib Across Clinical Programs.

Outcomes of maternal/paternal tofacitinib exposure were similar to those expected in the general population; tofacitinib should not be used during pregnancy unless clearly necessary.

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Role of Prucalopride in the Treatment of Chronic Constipation in Parkinson's Disease: A Randomized Controlled Trial.

Prucalopride was safe, well-tolerated, and more effective than placebo in increasing bowel movement frequency in PD patients with chronic constipation, supporting its potential as a therapeutic option in this population.

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Social Determinants of Health and Liver Transplant Outcomes in U.S. Indigenous Populations.

IPUS face SDOH challenges and lower rates of LT after waitlisting but can still achieve post-LT outcomes similar to non-IPUS patients.

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Clin Gastroenterol Hepatol
Associations Between Sexual Orientation and Disorders of Gut-Brain Interaction in Sexual Minority Populations.

Sexual orientation was independently associated with DGBI diagnoses among men, with no significant associations observed among women. These findings underscore the importance of considering gender-specific patterns when evaluating gastrointestinal health in sexual minority populations and highlight the need for tailored, inclusive approaches to DGBI care and research.

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Efficacy of Dupilumab on Facilitated Food Reintroduction in Eosinophilic Esophagitis.

Patients with EoE treated with dupilumab were able to safely reintroduce EoE trigger foods into their diet without exacerbation of histologic, endoscopic, or symptomatic measures of EoE severity. Some patients were able to reintroduce food at an earlier timepoint than others. , Number NCT05247866.

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Even Lower Alcohol Intake Might Be Harmful For East Asian Males With MASLD Spectrum.

East Asian men with MASLD had increased LRE risk at thresholds substantially.

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OCCASIONAL CONSTIPATION: PREVALENCE AND IMPACT IN THE ROME IV GLOBAL EPIDEMIOLOGY STUDY.

Rome-defined OC is common on a global scale, associated with psychological distress, reduced QoL, other Rome IV diagnoses, and high healthcare utilization.

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Resolution of metabolic dysfunction improves liver health among Chinese children: evidence from two prospective cohorts.

Metabolic dysfunction is a strong predictor of incident hepatic steatosis in children, and resolution of this dysfunction attenuates the attendant risk. These findings highlight the importance of primary and secondary interventions targeting metabolic risk factors to improve liver health in children.

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Endoscopy
Endoscopic eradication therapy with multifocal cryoballoon ablation for Barrett esophagus-related neoplasia: a prospective European multicenter study.

In expert hands, endoscopic eradication therapy with FCBA is highly effective in selected patients with BE of limited length, although the potential risk for stricture formation warrants further research.

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Gastrointest Endosc
A Novel Thin-Needle Knife with High-Pressure Waterjet for Colorectal Underwater Endoscopic Submucosal Dissection.

The high-pressure thin-needle knife appears to improve dissection speed with a favorable efficacy and safety profile.

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EFFICACY AND SAFETY OF A SELF-ASSEMBLING PEPTIDE HAEMOSTATIC GEL IN THE TREATMENT OF BLEEDING IN EUS-GUIDED DRAINAGE AND DIRECT ENDOSCOPIC NECROSECTOMY OF PANCREATIC FLUID COLLECTIONS.

This novel haemostatic gel is a safe andeffectiveto manage oozing bleedings related to PFCs EUS-guided drainage or DEN.

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Endoscopic submucosal dissection combined with endoscopic closure of gastrointestinal fistulas, including those refractory to prior treatment: results after descriptive series.

ESD with closure is safe and effective to cure fistulas, and could be considered part of the first-line treatment for naïve patients. In refractory patients, although of moderate efficacy, this technique could represent an alternative approach prior to salvage surgery.

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Impact of artificial intelligence-assisted colonoscopy on gastroenterology fellow performance: A pragmatic randomized controlled trial.

This pragmatic randomized controlled trial demonstrates that AI assisted colonoscopy improves RADR for gastroenterology trainees. Overall ADR was not significantly different between groups. We propose a use case via AI assisted colonoscopy for trainees guiding improvement of adenoma detection in the right colon and standardizing a critically needed colorectal cancer screening quality metric.

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Gut
Endoscopic or surgical gastroenterostomy for malignant gastric outlet obstruction: a randomised trial.

In this randomised trial, EUS-GE was superior to SGJ with regards to oral intake, need for reinterventions or supplemental nutrition, length of hospitalisation, quality of life and treatment costs.

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Gut microbial modulation of 3-hydroxyanthranilic acid and dopaminergic signalling influences attention in obesity.

We have identified the microbiota and 3-HAA as potential therapeutic targets to improve attention, especially in obesity.

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Hereditary diffuse gastric cancer spectrum associated with germline <i>CTNNA1</i> loss of function revealed by clinical and molecular data from 351 carrier families and over 37 000 non-carrier controls.

Background Diffuse gastric cancer (DGC) is the most common manifestation in germline -carrier individuals and families.

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Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies.

These early-phase findings suggest that VG161 elicits meaningful immune activation in ICC and supports further investigation. By inducing both direct oncolysis and multilayered immune activation, VG161 shows clinical benefit in a heavily pretreated population and holds promise for integration with CPI-based regimens. Validation in larger trials is warranted.

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Hepatology
Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma.

Our findings emphasize the therapeutic potential of combining nanotechnology and immunotherapy to reshape the TME and overcome immunotherapy resistance in fibrotic tumors, such as CCA. Targeting both ECM and immune checkpoints has emerged as a promising and versatile strategy to enhance the efficacy of immunotherapy against desmoplastic cancers.

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Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target.

Integrated multiomic characterization provides translational insights by defining unique molecular subtypes associated both with therapeutic response and overall clinical outcomes. This approach identified TNK1 as a previously unrecognized therapeutic target in a defined subset of CCA tumors.

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Pioneering precision: The evolution of immunotherapy for hepatocellular carcinoma.

In addition, several novel immunotherapeutic targets have been identified and treatments exploiting those targets are currently at early as well as late stages of clinical development. Herein, we review this evolution of immunotherapy for HCC which holds the potential for increasing therapeutic precision and thus for maximizing the benefit of patients while simultaneously reducing their risk of harm.

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J Hepatol
Genetic and non-genetic drivers of histological progression and regression in MASLD.

Genetic predisposition and its significant interactions with non-genetic factors drive the dynamic trajectory of MASLD, providing a critical framework for personalized risk stratification and management. Impact and implications Histological changes in metabolic dysfunction-associated steatotic liver disease are driven by complex interactions between genetic and non-genetic factors, not by isolated influences. The PNPLA3 rs738409 allele worsened fibrosis and steatosis, while the HSD17B13 rs72613567 allele acted as a protective factor against progression and promoted regression. A polygenic risk score (PRS), based on three single nucleotide polymorphisms, comprising the sum of the three risk alleles, independently predicted histological progression. Conversely, the PRS of the three non-risk alleles was associated with histological regression. Non-genetic factors such as age, sex, BMI changes, and type 2 diabetes mellitus significantly modified the impact of both single genetic variants and the PRS on histology. These findings underscore the necessity of considering these multifaceted interactions for personalized MASLD management, including risk stratification and future therapeutic development.

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Multicenter phase II trial of lenvatinib in patients with advanced hepatocellular carcinoma after progression on first-line atezolizumab plus bevacizumab.

Lenvatinib demonstrated promising efficacy and a manageable safety profile as a second-line treatment for patients with HCC progressing on atezo-bev. These findings offer prospective evidence supporting lenvatinib as a viable treatment option in the post-atezo-bev context. Impact and implications This study provides the first prospective evidence for the use of lenvatinib as a second-line therapy for patients with unresectable hepatocellular carcinoma who have progressed after first-line atezo-bev treatment. The findings highlight the potential of lenvatinib as a viable therapeutic option in a clinical setting where few alternatives are available. The results are particularly important for healthcare professionals managing unresectable hepatocellular carcinoma, as they provide a robust framework for considering lenvatinib in second-line treatment protocols. Given the manageable safety profile, these findings could be translated into practical recommendations for clinical practice, offering physicians a treatment strategy to improve patient outcomes following atezo-bev failure while guiding future research into combination therapies and broader patient populations. Clinical trial number NCT06138769.

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PARG inhibition halts cholangiocarcinoma progression via the Hippo pathway and enhances response to chemotherapy and immunotherapy.

Targeting PARG limits CCA progression, alleviates desmoplasia, and enhances response to both anti-PD-1 therapy and chemotherapy.

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Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis.

Background & aims Transforming growth factor-β signaling activated by α integrins, had a favorable safety and tolerability profile. This study supports targeting integrin-mediated transforming growth factor-β activation as a potential therapeutic approach for PSC.

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Transcriptomic and epigenetic mechanisms controlling cholangiocytes transdifferentiation into hepatocytes.

Overall, our results confirm that cholangiocytes can transdifferentiate into hepatocytes. This process is promoted by HNF4G, it involves epigenetic remodelling, and is consistent across the three liver lobes. This knowledge paves the way for future therapies aiming to enhance liver regeneration by increasing cholangiocytes' plasticity.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial: Chronic Hepatitis Delta-We Need More Screening to Improve Knowledge on the Natural History.

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Editorial: Is Disease Clearance the Target in Ulcerative Colitis or a Stride Too Far?

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Editorial: Terlipressin Induced Bradycardia.

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Clin Gastroenterol Hepatol
Blue Notes.

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J Hepatol
Engineered T-cell therapy for hepatocellular carcinoma: The dawn of precision immunotherapy?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
"Functional" GI Conditions in the Older Adult: DGBIs and Beyond.

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2025 CME Information.

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American College of Gastroenterology Monograph on Geriatrics and GI.

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Calendar of Courses, Symposiums and Conferences.

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Colorectal Cancer Screening and Surveillance and Other Colon Conditions in the Older Adult.

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Considerations in the Diagnoses and Management of Hepatic Disease in Older Adults.

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Correction to: Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study.

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Editor and Author Profiles.

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Gastro-Esophageal Disorders of the Geriatric Population.

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Letter to the Editor.

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Letter to the Editor.

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Monograph Conclusion.

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Pancreatic Cysts and Pancreatitis in the Older Adult.

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Practical Advice for the Management of Older Adults With Inflammatory Bowel Disease.

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Rallentando un Poco : Carvedilol and Its Role in Cirrhosis Progression.

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Response to Borras-Blasco et al.

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Vaccination Outcomes and Recommendations Among Older Adults in a Gastroenterology and Hepatology Practice.

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Clin Gastroenterol Hepatol
A decade of decreasing reimbursement strains gastroenterology practices and threatens their independence.

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High Prevalence of Difficult Readability of Gluten-Free Diet Recommendations for Celiac Disease Patients.

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Menopause May Partially Explain Age-related Increased Risk of MASLD Fibrosis: A Causal Mediation Analysis.

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Syphilitic Proctitis Mimicking Ulcerative Colitis.

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Tortoise Shell-like Gastric Mucosa.

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Endoscopy
A novel slim cholangioscope facilitates antegrade laser lithotripsy for an intrahepatic biliary stone with acute ductal angulation.

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Artificial intelligence for colorectal polyp sizing: clinical promise and methodological challenges.

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Calculus-targeted puncture technique to overcome access difficulty during endoscopic ultrasound-guided hepaticogastrostomy.

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Cholangioscopy-assisted endoscopic radial incision for benign biliary stricture.

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Clinical utility of long cap-assisted suction: two cases of food bolus and intraprocedural clot removal.

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Cross-shaped bridging stenting for malignant hilar biliary obstruction with surgically altered anatomy.

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Endoscopic full-thickness defect closure using a novel suture anchor device: a pilot survival porcine study.

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Endoscopic submucosal dissection of a large cavernous hemangioma in the proximal esophagus.

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Micro-endoscopic retrograde cholangiopancreatography catheter-assisted endoscopic laser lithotripsy: improving insertability and safety.

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Multiple transluminal gateway technique for drainage of an infected walled-off pancreatic necrosis and pancreatic pseudocyst.

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Pancreatic juice cytology via a nasopancreatic drainage tube placed using the rendezvous technique through the accessory pancreatic duct.

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Pitfall of endoscopic ultrasound-guided hepaticoduodenostomy: Impact of hepatic parenchymal volume during device insertion.

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Pitfalls of endoscopic ultrasound-guided gallbladder drainage using a lumen-apposing metal stent: impact of the intraluminal water-filling technique.

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Salvaging hilar access using an uneven double-lumen cannula in endoscopic ultrasound-guided hepaticogastrostomy.

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Snare traction-assisted ultra-long tunnel endoscopic resection of a giant exophytic cardia subepithelial tumor with diaphragmatic adherence.

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Gastroenterology
From Ongoing Fibrosis to Biopsy to Diagnosis: A Thorough Evaluation of Liver Granulomas in Clinical Practice.

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Learning to Tolerate: Searching for the Cells Responsible for Food Antigen Tolerance.

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Gastrointest Endosc
A Rare Perirectal Manifestation of Sarcoidosis Diagnosed with Trans-Rectal Ultrasound.

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Chylopericardium Following Endoscopic Radial Incision for Esophageal Stricture.

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Delayed adverse event of lumen-apposing metal stent.

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Endoscopic Removal of a Large Esophageal Leiomyoma via Bilateral Longitudinal-Transverse Tunneling After Failed Initial Resection.

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Endoscopic Ultrasound-Guided Transmural Drainage of a Pancreatic Pseudocyst in a Three-Year-Old Child.

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Target biopsy via slim dilating catheter for hilar cholangiocarcinoma.

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Gut
Aurora kinase B at the nexus of cholesterol metabolism and therapy response in cholangiocarcinoma.

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FODMAPs and functional dyspepsia: emerging evidence but unanswered questions.

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Hepatology
Global Hepatitis C elimination: Updates, challenges, and opportunities from real-world experiences in Europe and North America.

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Multi-omics and machine learning in cholangiocarcinoma: A paradigm shift toward molecular subtyping and precision therapy.

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Reply: Clarifying LSM cutoff validation, statistical power, and subgroup applicability in predicting liver- related events in chronic hepatitis B.

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J Hepatol
Kupffer cells are regulators of intergenerational signalling in MASLD.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Letter: Is Routine ECG Monitoring Redundant During Terlipressin Therapy in HRS-AKI?

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Letter: Temporal Trends in the Rate of Colectomy in Ulcerative Colitis.

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Clin Gastroenterol Hepatol
REPLY LETTER TO DR. CAMILLERI REGARDING "THE ASSESSMENT OF GASTROINTESTINAL TRANSIT BY THE ATMO CAPSULE".

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Gut
Reply: Prevalence of serum HBsAg <100 IU/mL in inactive chronic hepatitis B.

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Response to: 'Endoscopic intermuscular dissection for rectal cancer: are we ready to skip surgery?' by Ichimasa et al.

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J Hepatol
RIPK3 in acute decompensation of cirrhosis: Prognostic promise and analytic pitfalls.

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